| 400m Individual Medley | 4:58.53 | CRONK Carli |  USA | 09 May 2022 | Caxias do Sul, Brazil |
| 400m Individual Medley | 5:04.07 | HE Yue Yue |  CHN | 28 Jul 2013 | Sofia, Bulgaria |
| 400m Individual Medley | 5:08.21 | HE Yue Yue | CHN | 11 Sep 2009 | Taipei, Taiwan |
| 400m Individual Medley | 5:12.13 | BAILEY Cindy-Lu |  AUS | 11 Jul 1985 | Los Angeles, United States |
| 400m Individual Medley | 5:14.54 | BAILEY Cindy-Lu | AUS | 11 Jul 1985 | Los Angeles, United States |
| 400m Individual Medley | 5:21.60 | BARBER Laura | USA | 26 Jul 1981 | Köln, Germany |
| 400m Individual Medley | 5:23.73 | BARBER Laura | USA | 26 Jul 1981 | Köln, Germany |
| 400m Individual Medley | 5:31.19 | BARBER Laura | USA | 20 Jul 1977 | Bucharest, Romania |
| 400m Individual Medley | 5:36.62 | BARBER Laura | USA | 20 Jul 1977 | Bucharest, Romania |